CD Bioparticles has developed various Lipid System for research use, which can be applied in drug delivery, tracking & imaging, lipid synthesis and production, unique and functional liposome particle preparation and production, as well as adjuvants development for immunotherapy & vaccine development. These newly released sphingolipids products, along with other previously launched lipid systems, can support researcher in tackling problems in studies, such as inferior lipids, limited lipid options for customized lipid-based formulation, and tedious synthesis and production.
CD Bioparticles now offers various options for researchers in Sphingomyelin, for example, the N-acetyl-D-erythro-sphingosylphosphorylcholine (Catalog: CDLP-A1144). As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base.
However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts. Moreover, these membrane microdomains are thought to function as signaling platforms that regulate the localization and interaction of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts. Rather, it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.
As for Phytosphingosine & Derivatives, researchers are supplied with the N-24:0(2R-OH) Phytosphingosine (Catalog: CDLP-A1099) and several other products. D-ribo-phytosphingosines are biologically significant long-chain bases present in various sphingolipids from yeasts, fungi, plants and mammals. Phytosphingosine-1-phosphate has been identified as a lipid messenger mediating plant response to many metabolites.
Additionally, CD Bioparticles also provides Sphingosine-1-phosphate, D-erythro (Catalog: CDFCB013), which is an endogenous sphingolipid metabolite known to involve in many cellular responses including angiogenesis, vascular maturation, cardiac development and immunity, which are mediated through a family of 5 G-protein-coupled receptors.
For more details on sphingolipids products or more information about the lipid system, please visit CD Bioparticles at https://www.cd-bioparticles.net.
about CD Bioparticles
CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing new and biocompatible drug delivery systems. It specializes in a range of formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes for drug delivery to polymer microspheres and nanoparticles for enhanced drug delivery. It also provides contract services of drug delivery formulation for basic research, formulation feasibility studies, process development and scale-up, formulation characterization, as well as analytical and non-clinical services.
